2010

 
 

Alex Toker is an Associate Professor in the Department of Pathology at the Beth Israel Deaconess Medical Center, Harvard Medical School. The lab has membership in the Biological and Biomedical Sciences PhD Program and also the Dana-Farber/Harvard Cancer Center. The lab is located on the 6th floor of the new Center for Life Sciences building. 


Research in the laboratory focuses on the cell and molecular biology of cancer. We are investigating the mechanisms by which signaling pathways impact tumor cell survival, invasion and metastasis. The goal is to decipher the complex mechanisms by which these pathways impact cancer progression, with the ultimate goal of developing drugs to interfere with malignancy and metastasis.

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  1. BulletThe Toker lab welcomes new post-doctoral fellow Dr. Aura Kaunisto, who recently received her PhD from the University of Turku and the Turku Graduate School of Biomedical Sciences in Finland in the laboratory of John E. Eriksson. Welcome Aura!


  1. BulletThe Toker lab bids farewell to Amy Carr, lab manager and Research Assistant since 2007. Best of luck to Amy at MGH!


  1. BulletPaper published! Fry, J. S. and Toker, A. Secreted and membrane-bound isoforms of protease ADAM9 have opposing effects on breast cancer cell migration. Cancer Research 2010, doi:10.1158/0008-5472.CAN-09-4231


  1. BulletThe lab welcomes Heather Gardiner, new Research Assistant and Toker lab manager. Welcome Heather!


  1. BulletThe lab welcomes Whitney Henry, G1 student in the BBS PhD program, for her first lab rotation!


  1. BulletPaper published! Chin, Y. R. and Toker, A. The actin bundling protein Palladin is an Akt1-specific substrate that regulates breast cancer cell migration. Molecular Cell 2010, 38 (3) 333-344. 

  2. ‣   Read all about it in the BIDMC press release and video interview with the lab!

  3. ‣   Evaluated on Faculty of 1000


  1. BulletPaper published! Nhek, S., Ngo, M., Yang, X., Ng, M., Field, S. J., Asara, J. M., Ridgeway, N. D. and Toker, A. Regulation of OSBP Golgi Localization Through Protein Kinase D-mediated Phosphorylation.

        Molecular Biology of the Cell 2010, 21: 2327-2337.


  1. BulletRebecca Chin has been awarded an AACR-Women in Cancer Research Scholar Award! Congratulations Rebecca! Photos of the AACR WICR reception with Rebecca, other awardees along with 2010 Nobel Laureate Dr. Elizabeth Blackburn.


  1. BulletAlex Toker, Sivan Elloul, Rebecca Chin and Maria Mancini attended the 101st Annual AACR (American Association for Cancer Research) Meeting in Washington, DC, April 17-21, 2010. Alex co-chaired the Cancer Signaling mini-symposium, and Rebecca’s abstract was selected for an oral presentation, congratulations Rebecca! Photos here.


  1. BulletSivan Elloul has been awarded a Department of Defense 2010 Breast Cancer Research Program Post-doctoral fellowship! Congratulations Sivan!


  1. BulletAlex Toker attended the Cold Spring Harbor Laboratory on PTEN Pathways and Targets, March 16-20, 2010. Some photos here 


  1. BulletThe Toker lab welcomes two new post-doctoral fellows. Dr. Emilie Collmann, who recently received her PhD from the University of Basel, Switzerland, in the laboratory of Matthias Wymann. Dr. Kristin Brown, who received her PhD from the University of Otago, Christchurch, New Zealand, in the laboratory of Christine Winterbourn. Welcome!!


  1. BulletSokha Nhek has left the lab and joined ImClone Inc. in New York City for her post-doc. She is working in the laboratory of Dr. Laura Benjamin. Best of luck Sokha!!


  1. BulletJessica Fry has left the lab and joined the laboratory of Dr. Richard Cohen at Boston University School of Medicine for her post-doc. Best of luck Jessica!!


  1. BulletPreview Published! TTC3 Ubiquitination Terminates Akt-ivation. Toker A. Developmental Cell 2009: 17, 752-754


  1. BulletAlex Toker presented a seminar at the Institute of Cancer at Barts and the London School of Medicine and Dentistry, London, UK, on December 8 2009.


  1. BulletJessica Fry defended her PhD Thesis in the HMS Biological and Biomedical Sciences graduate program on November 19, 2009. The title of her Dissertation was ‘ADAM9 Metalloproteases and Breast Cancer Cell Migration’. Congratulations Dr. Jessica Fry!! Photos here.


  1. BulletAlex Toker presented a seminar at IRIC, Institut de Recherche en Immunologie et en Cancérologie, University of Montreal, Canada, on November 16 2009.


  1. BulletAlex Toker presented a seminar in the Department of Biochemistry and Molecular Biology at the Oregon Health & Science University in Portland, Oregon on November 10 2009.


  1. BulletReview Published! NFAT Proteins: Emerging Roles in Cancer Progression. Mancini, M. and Toker A.

    Nature Reviews Cancer 2009: 9, 810-820.


  1. BulletAlex Toker presented a seminar at the University of Arizona Cancer Center in Tucson on October 26 2009.


  1. BulletAlex Toker attended the workshop on Phospholipid Signaling and Transport, in memory of the late Prof. Moti Liscovitch, at the Weizmann Institute of Science in Rehovot, Israel, October 15, 2009. Photos here.


  1. BulletJessica Gasser was awarded a Department of Defense 2009 Breast Cancer Research Program Pre-doctoral fellowship! Congratulations Jess!


  1. BulletJessica Fry and Maria Mancini attended the AACR focused meeting on Frontiers in Basic Cancer Research in Boston, October 8-11, 2009. Jessica gave a poster presentation.


  1. BulletSokha Nhek defended her PhD Thesis in the HMS Biological and Biomedical Sciences graduate program on September 11, 2009. The title of her Dissertation was ‘Protein Kinase D Signaling Through Substrate Phosphorylation’. Congratulations Dr. Sokha Nhek!! Photos here. 


  1. BulletPaper published! Storz, P., Döppler, H., Copland, J. A., Simpson, K. J.  and Toker, A. The FOXO3a Transcription Factor Promotes Tumor Cell Invasion through the Induction of Matrix Metalloproteinases. Molecular and Cellular Biology 2009, 29 (18): 4906-4917.


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