2010

 
 

Alex Toker is an Associate Professor in the Department of Pathology at the Beth Israel Deaconess Medical Center, Harvard Medical School. The lab has membership in the Biological and Biomedical Sciences PhD Program at HMS, and also the Dana-Farber/Harvard Cancer Center. The lab is located on the 6th floor of the new Center for Life Sciences research building in the Longwood medical area. 


Research in the laboratory focuses on the cell and molecular biology of carcinoma progression. Specifically, we are investigating the mechanisms by which intracellular signaling pathways impact tumor cell survival, cell migration and invasion. The goal is to decipher the complex mechanisms by which these signaling pathways impact the behavior of cancer cells, with the ultimate goal of developing specific drugs which could interfere with the processes by which tumor cells become malignant and ultimately invade and metastasize.

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  1. BulletRebecca Chin and Maria Mancini will be attending the 101st Annual AACR (American Association for Cancer Research) Meeting in Washington, DC, April 17-21, 2010. Rebecca’s abstract was selected for an oral presentation, congratulations Rebecca!


  1. BulletSokha Nhek is leaving the lab and will be joining ImClone Inc. in New York City for her post-doc. She will be working in the laboratory of Dr. Laura Benjamin. Best of luck Sokha!!


  1. BulletJessica Fry is leaving the lab and will be joining the laboratory of Dr. Richard Cohen at Boston University School of Medicine for her post-doc. Best of luck Jessica!!


  1. BulletPreview Published! TTC3 Ubiquitination Terminates Akt-ivation. Toker A. Developmental Cell 2009: 17, 752-754


  1. BulletAlex Toker presented a seminar at the Institute of Cancer at Barts and the London School of Medicine and Dentistry, London, UK, on December 8 2009.


  1. BulletJessica Fry defended her PhD Thesis in the HMS Biological and Biomedical Sciences graduate program on November 19, 2009. The title of her Dissertation was ‘ADAM9 Metalloproteases and Breast Cancer Cell Migration’. Congratulations Dr. Jessica Fry!! Photos here.


  1. BulletAlex Toker presented a seminar at IRIC, Institut de Recherche en Immunologie et en Cancérologie, University of Montreal, Canada, on November 16 2009.


  1. BulletAlex Toker presented a seminar in the Department of Biochemistry and Molecular Biology at the Oregon Health & Science University in Portland, Oregon on November 10 2009.


  1. BulletReview Published! NFAT Proteins: Emerging Roles in Cancer Progression. Mancini, M. and Toker A. Nature Reviews Cancer 2009: 9, 810-820: doi: 10.1038/nrc2735.


  1. BulletAlex Toker presented a seminar at the University of Arizona Cancer Center in Tucson on October 26 2009.


  1. BulletAlex Toker attended the workshop on Phospholipid Signaling and Transport, in memory of the late Prof. Moti Liscovitch, at the Weizmann Institute of Science in Rehovot, Israel, October 15, 2009. Photos here.


  1. BulletJessica Gasser was awarded a Department of Defense 2009 Breast Cancer Research Program Pre-doctoral fellowship! Congratulations Jess!


  1. BulletJessica Fry and Maria Mancini attended the AACR focused meeting on Frontiers in Basic Cancer Research in Boston, October 8-11, 2009. Jessica gave a poster presentation.


  1. BulletSokha Nhek defended her PhD Thesis in the HMS Biological and Biomedical Sciences graduate program on September 11, 2009. The title of her Dissertation was ‘Protein Kinase D Signaling Through Substrate Phosphorylation’. Congratulations Dr. Sokha Nhek!! Photos here. 


  1. BulletPaper published! Storz, P., Döppler, H., Copland, J. A., Simpson, K. J.  and Toker, A. The FOXO3a Transcription Factor Promotes Tumor Cell Invasion through the Induction of Matrix Metalloproteinases. Molecular and Cellular Biology 2009, 29 (18): 4906-4917.



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