1. ‣Nhek, S., Ngo, M., Yang, X., Ng, M., Field, S. J., Asara, J. M., Ridgeway, N. D. and Toker, A. Regulation of OSBP Golgi Localization Through Protein Kinase D-mediated Phosphorylation Molecular Biology of the Cell 2010; 21: 2327-2337. Medline

  2. ‣Chin, Y. R. and Toker, A. The actin bundling protein Palladin is an Akt1-specific substrate that regulates breast cancer cell migration. Molecular Cell 2010; 38: 333-344. Medline

  3. ‣Maurer, M., Su, T., Saal, L. H., Koujak S., Hopkins B. D., Barkley C. R., Wu, J., Nandula S., Dutta, B., Xie Y., Chin Y. R., Kim, D.-I., Ferris, J. S., Gruvberger-Saal S. K., Laakso M., Wang X., Memeo L., Rojtman A., Matos T., Yu J. S., Cordon-Cardo C., Isola J., Terry M. B., Toker A., Mills G. B., Zhao J. J., Murty V. V. V. S., Hibshoosh H., and Parsons, R. 3-Phosphoinositide–Dependent Kinase 1 Potentiates Upstream Lesions on the Phosphatidylinositol 3-Kinase Pathway in Breast Carcinoma. Cancer Research 2009; 69 (15): 6299-6306. Medline

  4. ‣Storz, P., Döppler, H., Copland, J. A., Simpson, K. J.  and Toker, A. The FOXO3a Transcription Factor Promotes Tumor Cell Invasion through the Induction of Matrix Metalloproteinases. Molecular and Cellular Biology 2009; 29 (18): 4906-4917. Medline

  5. ‣Yoeli-Lerner, M., Chin, Y. R., Hansen, K. C. and Toker, A. The Akt/PKB and GSK-3b Signaling Pathway Regulates Cell Migration through the NFAT1 transcription factor. (2009) Molecular Cancer Research; 7(3): 425-432 Medline

  6. ‣Gao, D., Inuzuka, H., Tseng, A., Chin Y. R.,  Toker, A. and Wei, W. Akt Phosphorylates Skp2, Promotes its Cytoplasmic Localization, and Impairs its Destruction by APC/Cdh1. (2009) Nature Cell Biology; 11 (4): Medline

  7. ‣Yiu, G. K. and Toker, A. NFAT Induces Breast Cancer Cell Invasion by Promoting the Induction of Cyclooxygenase-2. (2006) J. Biol. Chem., 281 (18): 12210-12217. Medline

  8. ‣Yoeli-Lerner, M., Yiu, G. K., Erhardt, P., Jauliac, S. and Toker, A. Akt/PKB blocks breast cancer cell motility and invasion through the transcription factor NFAT.  (2005) Molecular Cell, 20: 539-550. Medline

  9. ‣Highlighted in Nature Reviews Molecular Cell Biology

  10. ‣Highlighted in a mini-review in Cancer Cell

  11. ‣Highlighted in Faculty of 1000

  12. ‣Highlighted in ReutersHealth and others.

  13. ‣Storz, P., Döppler, H. and Toker, A. Protein Kinase D Mediates Mitochondria-to-Nucleus Signaling and Detoxification from mROS. (2005) Mol. Cell. Bio., 25 (19): 8520-8530. Medline

            Highlighted in STKE.

  1. ‣Hausser, A., Storz, P., Märtens, S., Link, G., Toker, A. and Pfizenmaier, K. Protein kinase D regulates vesicular transport by phosphorylating and activating phosphatidylinositol-4-kinase IIIβ at the Golgi complex. (2005) Nature Cell Biology, 7: 880-886. Medline

  2. ‣Mazzocca, A., Coppari, R., De Franco, R., Cho, J.-Y., Libermann, T., Pinzani, M. and Toker, A. A secreted form of ADAM9 promotes tumor invasion through tumor-stromal interactions. (2005) Cancer Research, 65 (11): 4728-4738. Medline

  3. ‣Döppler, H., Storz, P., Li, J., Comb, M. J. and Toker, A.  A phosphorylation state-specific antibody recognizes HSP27, a novel substrate of protein kinase D. (2005) J. Biol. Chem., 280 (15): 15013-15019. Medline

  4. ‣Storz, P., Doppler, H., Ferran, C., Grey, S.T. and Toker, A. Functional Dichotomy of A20 in Apoptotic and Necrotic Cell Death. (2005) Biochem. J., 387: 47-55. Medline

  5. ‣Hutti, J. E., Jarrell E. T., Chang, J. D., Abbott D. W., Storz, P., Toker, A., Cantley, L. C. Turk, B. E. A rapid method for determining protein kinase phosphorylation specificity. (2004) Nature Methods, 1: 27-29. Medline

  6. ‣Storz, P., Döppler, H. and Toker, A. Activation Loop Phosphorylation Controls Protein Kinase D-Dependent Activation of Nuclear Factor k-B. (2004) Mol. Pharm., 66: 870-879. Medline

  7. ‣Storz, P., Döppler, H., and Toker, A. Protein kinase C delta selectively regulates protein kinase D-dependent activation of NF-kB in oxidative stress signaling.  (2004) Mol. Cell Bio., 24 (7): 2614-2626. Medline

  8. ‣Storz, P., Döppler, H., Johannes, F.-J. and Toker, A. Tyrosine phosphorylation of protein kinase D in the pleckstrin homology domain leads to activation. (2003) J. Biol. Chem., 278: 17969-17976. Medline

  9. ‣Storz, P. and Toker, A. Protein Kinase D Mediates a Stress-Induced NF-kB Activation and Survival Pathway. (2003) EMBO J., 22:109-120. Medline

  10. ‣Jauliac, S., López-Rodriguez, C., Shaw, L. M., Brown, L. F., Rao, A. and Toker, A. The Role of NFAT Transcription Factors in Integrin-Mediated Carcinoma Invasion. (2002) Nature Cell Biology, 4: 540-544. Medline

  11. ‣Highlighted in Science STKE

  12. ‣Highlighted in Nature Cancer Update.

  13. ‣Cenni, V., Döppler, H., Sonnenburg, E. D., Maraldi, N, Newton, A. C. and Toker, A. Regulation of Novel Protein Kinase C ε by Phosphorylation. (2002) Biochemical Journal, 363: 537-545. Medline

  14. ‣Toker, A. and Newton, A. C. Akt/PKB is Regulated by Autphosphorylation at the Hypothetical PDK-2 Site. (2000) J. Biol. Chem. 275: 8271-8274. Medline

  15. ‣Margaret M. Chou, Weimin Hou, Joanne Johnson, Lauren K. Graham, Mark H. Lee, Ching-Shih Chen, Alexandra C. Newton, Brian S. Schaffhausen and Alex Toker. Regulation of Protein Kinase Cζ by PI 3-Kinase and PDK-1. (1998) Current Biology: 8: 1069-1077. Medline

  16. ‣Thomas F. Franke, David R. Kaplan, Lewis C. Cantley and Alex Toker.  Direct Regulation of the Akt Proto-Oncogene Product by PtdIns-3,4-P2. (1997) Science 275: 665-668. Medline

Selected Primary Research Articles

  1. ‣Toker, A. TTC3 Ubiquitination Terminates Akt-ivation. Developmental Cell 2009; 17: 752-754. Medline

  2. ‣Mancini, M. and Toker, A. NFAT Proteins: Emerging Roles in Cancer Progression. (2009) Nature Reviews Cancer, 9, 810-820. Medline

  3. ‣Chin, Y. R. and Toker, A.  Function of Akt Signaling in Cell Motility, Invasion and the Tumor Stroma in Cancer. (2009) Cellular Signaling, 21(4):470-476. Medline

  4. ‣Toker, A. mTOR and Akt signaling in cancer: SGK cycles in. (2008) Molecular Cell, 31: 6-8. Medline

  5. ‣Toker, A. Akt signaling: a damaging interaction makes good. (2008) Trends in Biochemical Sciences, 33 (8): 356-359. Medline

  6. ‣Toker, A. Inhibiting the uninhibited: on the specificity of protein kinase inhibitors. (2007) Biochemical Journal

  7. ‣Yoeli-Lerner, M. and Toker, A. Akt/PKB Signaling in Cancer: A Function in Cell Motility and Invasion. (2006) Cell Cycle, 5(6): 603-605. Medline

  8. ‣Toker, A. and Yoeli-Lerner, M. Akt/PKB Signaling and Cancer – Surviving but not moving on. (2006) Cancer Research, 66 (8): 3963-3966. Medline

  9. ‣Toker, A. The biology and biochemistry of diacylglycerol signalling. (2005) EMBO Reports, 6: 310-314.  Medline

  10. ‣Storz, P. and Toker, A. NF-kB Signaling. An Alternate Pathway for Oxidative Stress Responses. (2003) Cell Cycle, 2:A8-A9. Medline

  11. ‣Toker, A. Phosphoinositide Kinases (2002) in Encyclopedia of Molecular Medicine. John Wiley & Sons, Inc., publishers, pp. 2477-2482.

  12. ‣Storz P. and Toker, A. 3’-Phosphoinositide-Dependent Kinase-1 (PDK-1) in PI 3-K Signaling. (2002) Frontiers in Bioscience, 7: d886-902. Medline

  13. ‣Toker, A. Regulation by Phosphorylation (2002) in Protein Kinase C, Dekker, L. editor. Landes Bioscience.

  14. ‣Toker, A. Phosphoinositides and Signal Transduction (2002) Cell and Molecular Life Sciences, 59: 761-779. Medline

  15. ‣Newton, A. C. and Toker, A. Cellular Regulation of Protein Kinase C (2001) in, Protein Adaptations and Signal Transduction, K. B. Storey and J. M. Storey, editors.  Elsevier Science, publishers pp.163-173.

  16. ‣Toker, A.  Protein Kinases as mediators of Phosphoinositide 3-Kinase Signaling.  (2000) Molecular Pharmacology.  57: 652-658. Medline

  17. ‣Toker, A. and Newton, A. C.  Cellular Signaling: Pivoting Around PDK-1. (2000) Cell. 103: 185-188. Medline

  18. ‣Toker, A. and Cantley, L. C. Signaling Through the Lipid Products of Phosphoinositide-3-OH Kinase. (1997) Nature 387: 673-676. Medline

  19. ‣Toker, A. Signaling through Protein Kinase C. (1998) Frontiers in Bioscience. 3: d1134-1147. Medline

  20. ‣Toker, A.  The Synthesis and Cellular Roles of PtdIns-4,5-P2.(1998) Curr. Opin. Cell. Biol. 10: 254-261. Medline

Selected Review Articles